MCB Konrad Bloch Lecture: Steven Henikoff
Northwest Science Building Lecture Hall
B-103, Oxford St., Cambridge
Thu., Apr. 19, 2018, 12 – 1 p.m.
We have developed genome-wide tools for high-resolution epigenomic mapping to provide mechanistic insights into nucleosome and transcription factor dynamics. Using a metabolic labeling approach, we have observed competition between nucleosomes and transcription factors behind the replication fork. We have identified asymmetrically unwrapped nucleosomes as structural features that result from transcription and remodeling. Our structural epigenomics strategy is general, including potential applications for non-invasive diagnosis of disease.
Gazette Classification: Lecture, Science
Organization/Sponsor: Department of Molecular & Cellular Biology
Speaker(s): Steven Henikoff, Member, Fred Hutchinson Cancer Research Center, Investigator, Howard Hughes Medical Institute