Nanolecture: Rapid In Vivo Assessment of the Nano/Bio Interface to Help Develop Safer Nanomaterials
Building 1, Room 1302
665 Huntington Ave.
Thu., May 24, 2018, 1 – 2 p.m.
While nanotechnology has significant potential to address numerous societal needs, innovators, policy makers and the public have concerns that the novel properties of engineered nanomaterials (ENMs) may cause harm. The number of new ENMs continues to outpace efforts to understand their impacts on biological systems. To keep pace, we have advanced the use of the zebrafish model to interrogate the interactions between ENMs and biological systems. Early developmental life stages are often uniquely sensitive to environmental insults, due in part to the enormous changes in cellular differentiation, proliferation and migration required to form the required cell types, tissues and organs. Thus, this life stage is the ideal life platform to determine if precision-engineered nanomaterials can target biological pathways. With small quantities of test materials, we broadly assess the impacts of ENM exposures on growth, organ development, cardiovascular function, and complex neurobehavior using high throughput screening (HTS) methods. Through automation, we use a systematic and iterative strategy to elucidate the nanomaterials properties that drive biological responses. To date, we have assessed hundreds of unique nanomaterials from a number of sources that span diverse classes of materials. This talk will discuss the detailed approaches, advantages, challenges and examples using HTS in vivo approaches to assess the biocompatibility of ENMs.
Gazette Classification: Environmental Sciences, Lecture
Organization/Sponsor: HSPH-NIEHS Nanosafety Center
Speaker(s): Robert Tanguay, Professor of Environmental and Molecular Toxicology, Oregon State University
More info: www.hsph.harvard.edu…